Structural and functional brain alterations in subthreshold depression: A multimodal coordinate-based meta-analysis.

Imaging studies of subthreshold depression (StD) have reported structural and functional abnormalities in a variety of spatially diverse brain regions. However, there is no consensus among different studies. In the present study, we applied a multimodal meta-analytic approach, the Activation Likelihood Estimation (ALE), to test the hypothesis that StD exhibits spatially convergent structural and functional brain abnormalities compared to healthy controls. A total of 31 articles with 25 experiments were included, collectively representing 1001 subjects with StD. We found consistent differences between StD and healthy controls mainly in the left insula across studies with various neuroimaging methods. Further exploratory analyses found structural atrophy and decreased functional activities in the right pallidum and thalamus in StD, and abnormal spontaneous activity converged to the middle frontal gyrus. Coordinate-based meta-analysis found spatially convergent structural and functional impairments in StD. These findings provide novel insights for understanding the neural underpinnings of subthreshold depression and enlighten the potential targets for its early screening and therapeutic interventions in the future.

Spontaneous brain activity associated with individual differences in decisional and emotional forgiveness.

Previous studies have explored the neural bases of forgiveness, however, the neural associations of decisional and emotional forgiveness remain unclear. Regional homogeneity (ReHo) and functional connectivity (FC) measured by resting-state functional magnetic resonance imaging (fMRI) were used to investigate the neural associations of individual differences in decisional and emotional forgiveness among healthy volunteers (256 participants, 85 males). The results of the ReHo analysis showed that decisional forgiveness was positively correlated with the left inferior parietal lobule (IPL). Furthermore, emotional forgiveness was positively correlated with the dorsal anterior cingulate cortex (dACC) and left supramarginal gyrus (SMG). The results of the FC analysis showed that decisional forgiveness was positively associated with the FC strength between the left IPL and left middle frontal gyrus (MFG) and negatively correlated with the FC strength among the left IPL, right superior temporal gyrus (STG), and left SMG. Furthermore, there was a significant positive correlation between emotional forgiveness and FC strength between the left SMG and right IPL. These findings suggest an association between decisional and emotional forgiveness and spontaneous brain activity in brain regions related to empathy, emotion regulation, and cognitive control.

The Effect of Pore Structure on Impact Behavior of Concrete Hollow Brick, Autoclaved Aerated Concrete and Foamed Concrete.

Porous concrete is an energy absorption material, which has been widely used in civil engineering, traffic engineering and disaster reduction engineering. However, the effect of pore structure on the impact behavior of the porous concrete is lacked. In this study, a series of drop-weight impact tests were carried out on three typical types of porous concrete, i.e., concrete hollow brick (CHB), autoclaved aerated concrete (AAC) and foamed concrete (FC), to investigate the effect of pore structures on their impact behavior. For comparison, static load tests were also conducted as references. According to the damage to the samples, the developments of impact force, strain, contact stress-strain relationship and absorbed energy during drop-weight during the impact test were measured and analyzed. The results show that the ratio between the peak impact stress and compressive strength of CHB was 0.44, while that of AAC and FC increased to about 0.6, indicating that the small and uniform pore structure in AAC and FC had a higher resistance against impact load than the hollow cavity of CHB. In addition, the elastic recovery strain in AAC increased by about 0.2% and its strain at peak contact stress increased by about 160% for a comparison of CHB, implying that a small open pore structure could enhance ductility. Besides, the peak contact stress of FC was close to that of AAC during impact loading, while the strain at peak contact stress of FC increased by about 36% compared with AAC, revealing that the closed-pore structure could further enhance the deformation potential. Correspondingly, the energy absorption rates of CHB, AAC and FC were 85.9 kJ/s, 54.4 kJ/s and 49.7 kJ/s, respectively, where AAC decreased by about 58% compared with CHB, and FC decreased by about 10% compared with AAC.

Influence of calcareous nodules content on scaling effect in shear strength of cohesive soil containing calcareous nodules.

The difference in the shear strength and other characteristics of the cohesive soil containing calcareous nodules (CSCN) between samples with large size and corresponding scaling size, which is called scaling effect, is significantly affected by its calcareous nodule content (CNC) of the gradation composition. However, current researches rarely reveal the influence of the CNC on the scaling effect in shear strength of samples. In this study, how and why the CNC affects the scaling effect in shear strength were explored. Then a method to reduce the scaling effect based on the reason for influence was proposed. Results show that the correlation between the scaling effect in shear strength and the CNC presents a step curve. This is attributed to that it is easier to form a skeleton effect in samples with scaling size for the same CNC. Considering the skeleton effect, a calculation model for the shear strength parameters of CSCN samples with large size is proposed to reduce the scaling effect. This paper demonstrates that the proposed calculation model provides an access to obtain calculated shear strength parameters of CSCN samples with large size by using measured results of samples with corresponding scaling size.